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Adriamycin RDF (hydrochloride salt)

Adriamycin

CAS: 23214-92-8

Molecular Formula: C27H29NO11

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Adriamycin RDF (hydrochloride salt) - Names and Identifiers

Name Adriamycin
Synonyms Rubex
Adriacin
ADRIAMYCIN
Adriamycin
DOXORUBICIN
Adriblastin
Doxorubicin
Adriblastina
Adriamycin PFS
Adriamycin RDF
14-Hydroxydaunomycin
Adriamycin Adriamycin
Doxorubicin hydrohloride
Rubex (hydrochloride salt)
Adriacin (hydrochloride salt)
adriblatina (hydrochloride salt)
adiblastine (hydrochloride salt)
Adriblastina (hydrochloride salt)
adriablatina (hydrochloride salt)
adriablastine (hydrochloride salt)
Farmablastina (hydrochloride salt)
Adriamycin RDF (hydrochloride salt)
Adriamycin PFS (hydrochloride salt)
Doxorubicin hydrochloride (hydrochloride salt)
Hydroxydaunomycin hydrochloride (hydrochloride salt)
Hydroxydaunorubicin hydrochloride (hydrochloride salt)
10-((3-amino-2,3,6-trideoxy-alpha-l-lyso-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
10-((3-Amino-2,3,6-trideoxy-alpha-L-lyso-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
(1s,3s)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranoside
(1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
(8S-cis)-10-(3-Amino-2,3,6-Trideoxy-alpha-L-Lyxo-Hexopyranosyl)Oxy-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxy-5,12-Naphthacenedione
5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, (8S,10S)-
CAS 23214-92-8
EINECS 245-495-6
InChI InChI=1/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1

Adriamycin RDF (hydrochloride salt) - Physico-chemical Properties

Molecular FormulaC27H29NO11
Molar Mass543.53
Density1.3783 (rough estimate)
Melting Point205°C
Boling Point617.77°C (rough estimate)
Flash Point443.8°C
Water SolubilitySoluble
Vapor Presure9.64E-28mmHg at 25°C
pKapKa 8.2 (Uncertain)
Storage ConditionKeep in dark place,Sealed in dry,2-8°C
Refractive Index1.6400 (estimate)
Physical and Chemical PropertiesThe hydrochloride is an orange-red needle-like crystal. Melting Point 204-205 °c. Soluble in water, methanol. The aqueous solution was stable. Insoluble in benzene, ether, chloroform.
UseClinical for acute and chronic lymphocytic leukemia and solid tumor treatment. This product adverse reactions have myelosuppression myocardial toxicity.

Adriamycin RDF (hydrochloride salt) - Risk and Safety

ToxicityAn anthracycline cytotoxic
antineoplastic that is produced by Streptomyces peucetius. The
LD50 in mice is 9.4 mg/kg, i.v. It is a carcinogen that inhibits
DNA and RNA synthesis by intercalating in double-stranded
DNA with the amino sugar in the minor groove and the 90-OH
group of the anthracycline ring hydrogen-bonded to the adjacent
guanine. It also alters membrane fluidity and ion transport, and
generates free radicals through a cytochrome P450-mediated
reductive process. In humans, it causes alopecia, stomatitis, nausea,
vomiting, diarrhea, cardiotoxicity (manifested by tachycardia),
and potentially fatal congestive heart failure.
Adriamycin RDF (hydrochloride salt)
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CAS: 23214-92-8
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Shanghai Macklin Biochemical Co., Ltd
Featured ProductsSpot supply
Product Name: Adriamycin Visit Supplier Webpage Request for quotation
CAS: 23214-92-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Featured ProductsSpot supply
Product Name: Doxorubicin Visit Supplier Webpage Request for quotation
CAS: 23214-92-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
MedChemExpress (MCE)
Spot supply
Product Name: Doxorubicin Visit Supplier Webpage Request for quotation
CAS: 23214-92-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
View History
Adriamycin RDF (hydrochloride salt)
(2E)-2-甲基-3-苯基丙烯酸
Cross-linked dextran gel G-75
TRANEXAMIC ACID
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